Article
An updated review on abnormal epigenetic modifications in the pathogenesis of systemic lupus erythematosus.
Frontiers in immunology - 1 Jan 2024
Zhou Xingyu, Zhou Shengnan, Li Yaping
Abstract excerpt
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. The inconsistent prevalence of SLE between monozygotic twins suggests that environmental factors affect the occurrence of this disease. Abnormal epigenetic regulation is strongly associated with the pathogenesis of SLE. Epigenetic mechanisms may be involved in the development of lupus through DNA methylation, histone modification, noncoding RNAs,...
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