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Article

Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Feb 2013

Melnikova Tatiana, Fromholt Susan, Kim HyunSu, Lee Deidre, Xu Guilian, Price Ashleigh, Moore Brenda D, Golde Todd E, Felsenstein Kevin M, Savonenko Alena, Borchelt David R

Abstract excerpt

Transgenic mice that express mutant amyloid precursor protein (APPsi) using tet-Off vector systems provide an alternative model for assessing short- and long-term effects of Aβ-targeting therapies on phenotypes related to the deposition of Alzheimer-type amyloid. Here we use such a model, termed APPsi:tTA, to determine what phenotypes persist in mice with high amyloid burden after new production of APP/Aβ has...

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Source

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Identifiers

PMID: 23447589
DOI: 10.1523/JNEUROSCI.4251-12.2013
PMCID: PMC3711622

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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