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Article

Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes.

BMC medical genetics - 15 Feb 2011

Lange Nancy E, Zhou Xiaobo, Lasky-Su Jessica, Himes Blanca E, Lazarus Ross, Soto-Quirós Manuel, Avila Lydiana, Celedón Juan C, Hawrylowicz Catherine M, Raby Benjamin A, Litonjua Augusto A

Abstract excerpt

BACKGROUND: Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts. METHODS: rs5743836 was genotyped in two family-based cohorts of children with asthma...

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Source

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Identifiers

PMID: 21324137
DOI: 10.1186/1471-2350-12-26
PMCID: PMC3048492

Genes

TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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