Article
Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells.
The Journal of biological chemistry - 15 Jun 2007
Ranjith-Kumar C T, Miller William, Sun Jingchuan, Xiong Jin, Santos Jon, Yarbrough Ian, Lamb Roberta J, Mills Juliane, Duffy Karen E, Hoose Scott, Cunningham Mark, Holzenburg Andreas, Mbow M Lamine, Sarisky Robert T, Kao C Cheng
Abstract excerpt
Recognition of double-stranded RNA by Toll-like receptor 3 (TLR3) will increase the production of cytokines and chemokines through transcriptional activation by the NF-kappaB protein. Over 136 single-nucleotide polymorphisms (SNPs) in TLR3 have been identified in the human population. Of these, four alter the sequence of the TLR3 protein. Molecular modeling suggests that two of the SNPs, N284I and L412F, could...
Topics
Join the communities discussing this publication.