Article
Putative association of a TLR9 promoter polymorphism with atopic eczema.
Allergy - 1 Jul 2007
Novak N, Yu C-F, Bussmann C, Maintz L, Peng W-M, Hart J, Hagemann T, Diaz-Lacava A, Baurecht H-J, Klopp N, Wagenpfeil S, Behrendt H, Bieber T, Ring J, Illig T, Weidinger S
Abstract excerpt
BACKGROUND: Toll-like receptors (TLR) play a pivotal role in the induction of first-line defense mechanisms of the innate immune system and trigger adaptive immune responses to microbial pathogens. Genetic variations in innate immunity genes have been reported to be associated with a range of inflammatory disorders. Deficiencies on the level of immunity receptors such as pathogen-recognition receptors are...
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