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Article

Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes.

American journal of respiratory and critical care medicine - 1 Dec 2002

Raby Benjamin A, Klimecki Walter T, Laprise Catherine, Renaud Yannick, Faith Janet, Lemire Mathieu, Greenwood Celia, Weiland Katherine M, Lange Christoph, Palmer Lyle J, Lazarus Ross, Vercelli Donata, Kwiatkowski David J, Silverman Edwin K, Martinez Fernando D, Hudson Thomas J, Weiss Scott T

Abstract excerpt

Toll-like receptor 4 (TLR4) is the principal receptor for bacterial endotoxin recognition, and functional variants in the gene confer endotoxin-hyporesponsiveness in humans. Furthermore, there is evidence that endotoxin exposure during early life is protective against the development of atopy and asthma, although this relationship remains poorly understood. It is therefore possible that genetic variation in the...

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Identifiers

PMID: 12406828
DOI: 10.1164/rccm.200207-634OC

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes.PMID 12406828Read ↗

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