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Article

Polymorphisms in toll-like receptor 4 gene are associated with asthma severity but not susceptibility in a Chinese Han population.

Journal of investigational allergology & clinical immunology - 1 Jan 2011

Zhang Q, Qian F H, Zhou L F, Wei G Z, Jin G F, Bai J L, Yin K S

Abstract excerpt

BACKGROUND AND OBJECTIVES: The toll-like receptor 4 (TLR4) gene links human innate immunity and adaptive immunity via bacterial endotoxin recognition, and plays a considerable role in the pathogenesis of asthma. The effects of the genetic variants of TLR4 on asthma are still largely unknown. This study aimed to evaluate the effects of TLR4 polymorphisms on asthma risk and asthma-related phenotypes in a Chinese...

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PMID: 21905500

Genes

TLR4

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