Article
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
The New England journal of medicine - 17 Feb 2011
Stanescu Horia C, Arcos-Burgos Mauricio, Medlar Alan, Bockenhauer Detlef, Kottgen Anna, Dragomirescu Liviu, Voinescu Catalin, Patel Naina, Pearce Kerra, Hubank Mike, Stephens Henry A F, Laundy Valerie, Padmanabhan Sandosh, Zawadzka Anna, Hofstra Julia M, Coenen Marieke J H, den Heijer Martin, Kiemeney Lambertus A L M, Bacq-Daian Delphine, Stengel Benedicte, Powis Stephen H, Brenchley Paul, Feehally John, Rees Andrew J, Debiec Hanna, Wetzels Jack F M, Ronco Pierre, Mathieson Peter W, Kleta Robert
Abstract excerpt
BACKGROUND: Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of biopsy-proven cases of idiopathic membranous nephropathy in a white population. METHODS: We performed independent genomewide association studies of single-nucleotide polymorphisms (SNPs) in patients with idiopathic membranous...
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