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Article

Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy.

Journal of the American Society of Nephrology : JASN - 1 Mar 2013

Coenen Marieke J H, Hofstra Julia M, Debiec Hanna, Stanescu Horia C, Medlar Alan J, Stengel Bénédicte, Boland-Augé Anne, Groothuismink Johanne M, Bockenhauer Detlef, Powis Steve H, Mathieson Peter W, Brenchley Paul E, Kleta Robert, Wetzels Jack F M, Ronco Pierre

Abstract excerpt

The M-type receptor for phospholipase A2 (PLA2R1) is the major target antigen in idiopathic membranous nephropathy (iMN). Our recent genome-wide association study showed that genetic variants in an HLA-DQA1 and phospholipase A2 receptor (PLA2R1) allele associate most significantly with biopsy-proven iMN, suggesting that rare genetic variants within the coding region of the PLA2R1 gene may contribute to antibody...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glomerulonephritis, Membranous

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Share to Polymorphism, Single Nucleotide

Share to Renal Diseases and Glomerulopathies

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Identifiers

PMID: 23431073
DOI: 10.1681/ASN.2012070730
PMCID: PMC3609136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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