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Genetics of membranous nephropathy

25 Sept 2017

Abstract excerpt

An HLA-DR3 association with membranous nephropathy (MN) was described in 1979 and additional evidence for a genetic component to MN was suggested in 1984 in reports of familial MN. In 2009, a pathogenic autoantibody was identified against the phospholipase A2 receptor 1 (PLA2R1). Here we discuss the genetic studies that have proven the association of human leucocyte antigen class II and PLA2R1 variants and...

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PMID: 29126273
DOI: 10.1093/ndt/gfx296

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