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Article

MHC Class II Risk Alleles and Amino Acid Residues in Idiopathic Membranous Nephropathy.

Journal of the American Society of Nephrology : JASN - 1 May 2017

Cui Zhao, Xie Li-Jun, Chen Fang-Jin, Pei Zhi-Yong, Zhang Li-Jie, Qu Zhen, Huang Jing, Gu Qiu-Hua, Zhang Yi-Miao, Wang Xin, Wang Fang, Meng Li-Qiang, Liu Gang, Zhou Xu-Jie, Zhu Li, Lv Ji-Cheng, Liu Fan, Zhang Hong, Liao Yun-Hua, Lai Lu-Hua, Ronco Pierre, Zhao Ming-Hui

Abstract excerpt

Epitopes of phospholipase A2 receptor (PLA2R), the target antigen in idiopathic membranous nephropathy (iMN), must be presented by the HLA-encoded MHC class II molecules to stimulate autoantibody production. A genome-wide association study identified risk alleles at HLA and PLA2R loci, with the top variant rs2187668 within HLA-DQA1 showing a risk effect greater than that of the top variant rs4664308 within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27852637
DOI: 10.1681/ASN.2016020114
PMCID: PMC5407714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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