Article
Variants in the Promoter Region of HLA-DQA1 were Associated with Idiopathic Membranous Nephropathy in a Chinese Han Population.
Chinese medical journal - 20 Jul 2017
Qin Xiao-Song, Liu Jian-Hua, Lyu Guan-Ting, Peng Meng-Le, Yang Fu-Ning, Qin Dong-Chun, Li Yong-Zhe, Liu Yong
Abstract excerpt
BACKGROUND: Idiopathic membranous nephropathy (IMN) is an autoimmune disease and the leading cause of adult nephritic syndrome. HLA-DQA1 had been identified to be associated with IMN in Europeans and the result was replicated in Chinese Han population. In this study, six single nucleotide polymorphisms (SNPs) in the promoter of HLA-DQA1 and other two SNPs with IgA nephropathy were included for the association...
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