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Article

Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice.

Behavioral and brain functions : BBF - 8 Dec 2014

Arime Yosefu, Fukumura Ryutaro, Miura Ikuo, Mekada Kazuyuki, Yoshiki Atsushi, Wakana Shigeharu, Gondo Yoichi, Akiyama Kazufumi

Abstract excerpt

BACKGROUND: Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder and major depression. Several previous studies reported that mice with N-ethyl-N-nitrosourea (ENU)-induced L100P mutation in Disc1 sho...

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Source

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Identifiers

PMID: 25487992
DOI: 10.1186/1744-9081-10-45
PMCID: PMC4295473

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25487992-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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