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Article

Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jan 2014

Kaminitz Ayelet, Barzilay Ran, Segal Hadar, Taler Michal, Offen Daniel, Gil-Ad Irit, Mechoulam Raphael, Weizman Abraham

Abstract excerpt

UNLABELLED: OBJECTIVES. Disrupted in schizophrenia 1 (DISC1) is considered the most prominent candidate gene for schizophrenia. In this study, we aimed to characterize behavioural and brain biochemical traits in a mouse expressing a dominant negative DISC1mutant (DN-DISC1). METHODS: DN-DISC1 mice underwent behavioural tests to evaluate object recognition, social preference and social novelty seeking. ELISA was...

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Source

Identifiers

PMID: 24219803
DOI: 10.3109/15622975.2013.841993

Genes

DISC1
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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