Polymorphisms of the pfmdr1 but not the pfnhe-1 gene is associated with in vitro quinine sensitivity in Thai isolates of Plasmodium falciparum.

doi:10.1186/1475-2875-11-7

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Article

Polymorphisms of the pfmdr1 but not the pfnhe-1 gene is associated with in vitro quinine sensitivity in Thai isolates of Plasmodium falciparum.

Malaria journal - 5 Jan 2012

Poyomtip Teera, Suwandittakul Nantana, Sitthichot Narumon, Khositnithikul Rommanee, Tan-ariya Peerapan, Mungthin Mathirut

Abstract excerpt

BACKGROUND: The emergence of Plasmodium falciparum resistance to most currently used anti-malarial drugs is a major problem in malaria control along the Thai-Myanmar and Thai-Cambodia borders. Quinine (QN) with tetracycline/doxycycline has been used as the second-line treatment for uncomplicated falciparum malaria. In addition, QN monotherapy has been the first-line treatment for falciparum malaria in pregnant...

Topics

Antimalarials
Cambodia
DNA, Protozoan
Female
Humans
Inhibitory Concentration 50
Malaria, Falciparum
Multidrug Resistance-Associated Proteins
Myanmar
Parasitic Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium falciparum

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Polymorphism, Single Nucleotide

Pregnancy

Quinine

Sodium-Hydrogen Exchangers

Thailand

Source

Open in PubMed Open full text

Identifiers

PMID: 22221394
DOI: 10.1186/1475-2875-11-7
PMCID: PMC3287963

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22221394-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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