Article
In vitro activity of ferroquine is independent of polymorphisms in transport protein genes implicated in quinoline resistance in Plasmodium falciparum.
Antimicrobial agents and chemotherapy - 1 Aug 2008
Henry Maud, Briolant Sébastien, Fontaine Albin, Mosnier Joel, Baret Eric, Amalvict Rémy, Fusaï Thierry, Fraisse Laurent, Rogier Christophe, Pradines Bruno
Abstract excerpt
The in vitro activity of ferroquine (FQ) (SR97193), a 4-aminoquinoline antimalarial compound that contains a ferrocenic nucleus, against 15 Plasmodium falciparum strains was assessed and compared with those of chloroquine (CQ), quinine (QN), monodesethylamodiaquine (MDAQ), and mefloquine (MQ). These 15 strains were genotyped for polymorphisms in quinoline resistance-associated genes such as Pfcrt, Pfmdr1, Pfmrp,...
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