Article
LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Feb 2011
Piccoli Giovanni, Condliffe Steven B, Bauer Matthias, Giesert Florian, Boldt Karsten, De Astis Silvia, Meixner Andrea, Sarioglu Hakan, Vogt-Weisenhorn Daniela M, Wurst Wolfgang, Gloeckner Christian Johannes, Matteoli Michela, Sala Carlo, Ueffing Marius
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson's disease. Little is known about its involvement in the pathogenesis of Parkinson's disease mainly because of the lack of knowledge about the physiological role of LRRK2. To determine the function of LRRK2, we studied the impact of short hairpin RNA-mediated silencing of LRRK2 expression in cortical neurons....
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