Article
PRRT2 Regulates Synaptic Fusion by Directly Modulating SNARE Complex Assembly.
Cell reports - 16 Jan 2018
Coleman Jeff, Jouannot Ouardane, Ramakrishnan Sathish K, Zanetti Maria N, Wang Jing, Salpietro Vincenzo, Houlden Henry, Rothman James E, Krishnakumar Shyam S
Abstract excerpt
Mutations in proline-rich transmembrane protein 2 (PRRT2) are associated with a range of paroxysmal neurological disorders. PRRT2 predominantly localizes to the pre-synaptic terminals and is believed to regulate neurotransmitter release. However, the mechanism of action is unclear. Here, we use reconstituted single vesicle and bulk fusion assays, combined with live cell imaging of single exocytotic events in PC12...
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