Article
The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression.
Breast cancer research : BCR - 9 Feb 2011
Chan Peter, Möller Andreas, Liu Mira C P, Sceneay Jaclyn E, Wong Christina S F, Waddell Nic, Huang Katie T, Dobrovic Alexander, Millar Ewan K A, O'Toole Sandra A, McNeil Catriona M, Sutherland Robert L, Bowtell David D, Fox Stephen B
Abstract excerpt
INTRODUCTION: The seven in absentia homolog 2 (SIAH2) protein plays a significant role in the hypoxic response by regulating the abundance of hypoxia-inducible factor-α; however, its role in breast carcinoma is unclear. We investigated the frequency and expression pattern of SIAH2 in two independent cohorts of sporadic breast cancers. METHODS: Immunohistochemical evaluation of SIAH2protein expression was...
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