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Siah1 in cancer and nervous system diseases (Review)

23 Dec 2021

Abstract excerpt

The dysregulation of the ubiquitin‑proteasome system will result in the abnormal accumulation and dysfunction of proteins, thus leading to severe diseases. Seven in absentia homolog 1 (Siah1), an E3 ubiquitin ligase, has attracted wide attention due to its varied functions in physiological and pathological conditions, and the numerous newly discovered Siah1 substrates. In cancer and nervous system diseases, the...

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PMID: 34958110
DOI: 10.3892/or.2021.8246

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