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Nuclear accumulation of seven in absentia homologue‐2 supports motility and proliferation of liver cancer cells

9 Feb 2012

Abstract excerpt

Stability of many tumor-relevant proteins is partly mediated by E3 ligases, which determine substrate specificity within the ubiquitin system. Recent data demonstrated that increased nuclear expression of the E3 ligase seven in absentia homologue (SIAH)-1 in human hepatocarcinogenesis supports tumor cell proliferation and migration. To define whether closely related SIAH-2 synergizes with protumorigenic SIAH-1,...

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PMID: 22323152
DOI: 10.1002/ijc.27473

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