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Article

SIAH proteins: critical roles in leukemogenesis.

Leukemia - 1 Apr 2013

Krämer O H, Stauber R H, Bug G, Hartkamp J, Knauer S K

Abstract excerpt

The delicate balance between the synthesis and the degradation of proteins ensures cellular homeostasis. Proteases act in an irreversible manner and therefore have to be strictly regulated. The ubiquitin-proteasome system (UPS) is a major pathway for the proteolytic degradation of cellular proteins. As dysregulation of the UPS is observed in most cancers including leukemia, the UPS is a valid target for...

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Source

Identifiers

PMID: 23038274
DOI: 10.1038/leu.2012.284

Genes

SIAH1
SIAH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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