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Article

A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.

Journal of human genetics - 1 Dec 2012

Elgazzar Seham, Zembutsu Hitoshi, Takahashi Atsushi, Kubo Michiaki, Aki Fuminori, Hirata Koichi, Takatsuka Yuichi, Okazaki Minoru, Ohsumi Shozo, Yamakawa Takashi, Sasa Mitsunori, Katagiri Toyomasa, Miki Yoshio, Nakamura Yusuke

Abstract excerpt

In Japan, breast cancer is the most common cancer among women and the second leading cause of cancer death among women worldwide. To identify genetic variants associated with the disease susceptibility, we performed a genome-wide association study (GWAS) using a total of 1086 Japanese female patients with hormonal receptor-positive (HRP) breast cancer and 1816 female controls. We selected 33 single-nucleotide...

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Share to Breast Neoplasms
Share to Carcinoma, Intraductal, Noninfiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 3

Share to Neoplasms, Hormone-Dependent

Share to Nuclear Proteins

Share to Receptor, Fibroblast Growth Factor, Type 2

Share to Receptors, Estrogen

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 22951594
DOI: 10.1038/jhg.2012.108

Genes

SIAH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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