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Article

Siah1 promotes the proliferation of NSCLC cells through ubiquitinating and stabilizing Notch1

9 Aug 2022

Abstract excerpt

Seven in absentia homolog 1 (Siah1) has been shown plays important roles in the pathogenesis and development of multiple cancers. However, the functions and mechanisms of Siah1 in non-small cell lung cancer (NSCLC) remain unclear. In our study, we found that knock down of Siah1 could inhibit the proliferation of NSCLC cells, while over-expression of Siah1 had the opposite effects. Molecularly, the bioinformatics...

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Identifiers

PMID: 35961388
DOI: 10.1016/j.yexcr.2022.113305

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