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Article

Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer.

Genes, chromosomes & cancer - 1 May 2011

Vaughn Cecily P, Zobell Scott D, Furtado Larissa V, Baker Christine L, Samowitz Wade S

Abstract excerpt

Mutational analysis of KRAS codons 12 and 13 is standard for patients with metastatic colorectal cancer since mutations in these codons predict lack of response to anti-EGFR therapies. However, even among patients whose tumors are wildtype for KRAS codons 12 and 13, only a subset respond to therapy. Since additional activating mutations downstream of EGFR may also play a role in treatment resistance, we sought to...

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Source

Identifiers

PMID: 21305640
DOI: 10.1002/gcc.20854

Genes

KRAS
BRAF
EGFR
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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