Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.

doi:10.1186/1476-4598-13-135

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Article

Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.

Molecular cancer - 31 May 2014

Imamura Yu, Lochhead Paul, Yamauchi Mai, Kuchiba Aya, Qian Zhi Rong, Liao Xiaoyun, Nishihara Reiko, Jung Seungyoun, Wu Kana, Nosho Katsuhiko, Wang Yaoyu E, Peng Shouyong, Bass Adam J, Haigis Kevin M, Meyerhardt Jeffrey A, Chan Andrew T, Fuchs Charles S, Ogino Shuji

Abstract excerpt

BACKGROUND: KRAS mutations in codons 12 and 13 are established predictive biomarkers for anti-EGFR therapy in colorectal cancer. Previous studies suggest that KRAS codon 61 and 146 mutations may also predict resistance to anti-EGFR therapy in colorectal cancer. However, clinicopathological, molec...

Topics

Aged
Class I Phosphatidylinositol 3-Kinases
Codon
Cohort Studies
Colorectal Neoplasms
CpG Islands
DNA Methylation
ErbB Receptors
Female
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Long Interspersed Nucleotide Elements

Male

Middle Aged

Mutation

Phosphatidylinositol 3-Kinases

Proportional Hazards Models

Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24885062
DOI: 10.1186/1476-4598-13-135
PMCID: PMC4051153

Genes

KRAS
BRAF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24885062-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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