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Article

Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer.

BMC cancer - 25 Feb 2021

Araujo Luiz Henrique, Souza Bianca Mendes, Leite Laura Rabelo, Parma Sabrina A F, Lopes Natália P, Malta Frederico S V, Freire Maíra C M

Abstract excerpt

BACKGROUND: KRAS is the most frequently mutated oncogene in cancer, however efforts to develop targeted therapies have been largely unsuccessful. Recently, two small-molecule inhibitors, AMG 510 and MRTX849, have shown promising activity in KRAS G12C-mutant solid tumors. The current study aims to assess the molecular profile of KRAS G12C in colorectal (CRC) and non-small-cell lung cancer (NSCLC) tested in a...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung
Colorectal Neoplasms
Female
GTP Phosphohydrolases
Humans
Lung Neoplasms
Male
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Proto-Oncogene Proteins p21(ras)

Retrospective Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 33632153
DOI: 10.1186/s12885-021-07884-8
PMCID: PMC7905642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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