Article
[Detection of KRAS gene mutations in colorectal carcinoma: a study of 6 364 patients].
Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Sept 2014
Wang Dong, Liang Wang, Duan Xiaowei, Liu Ling, Shen Hao, Peng Yongji, Li Bin
Abstract excerpt
OBJECTIVE: To investigate the mutation rate and types of KRAS gene in colorectal carcinoma of Chinese patients, and to document the regional distribution of the mutation. METHODS: A total of 6 364 colorectal carcinoma tumor specimens were obtained from 27 provinces and autonomous regions in China from 2009 to 2013. Pyrosequencing was used to detect mutations in codons 12 and 13 of KRAS gene. The mutation types of...
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