Article
NRAS mutations are rare in colorectal cancer.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Sept 2010
Irahara Natsumi, Baba Yoshifumi, Nosho Katsuhiko, Shima Kaori, Yan Liying, Dias-Santagata Dora, Iafrate Anthony John, Fuchs Charles S, Haigis Kevin M, Ogino Shuji
Abstract excerpt
Activating mutations in members of the RAS oncogene family (KRAS, HRAS, and NRAS) have been found in a variety of human malignancies, suggesting a dominant role in carcinogenesis. In colon cancers, KRAS mutations are common and clearly contribute to malignant progression. The frequency of NRAS mutations and their relationship with clinical, pathologic, and molecular features remains uncertain. We developed and...
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