Article
Clinicopathologic characteristics and gene expression analyses of non-KRAS 12/13, RAS-mutated metastatic colorectal cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Oct 2014
Morris V K, Lucas F A San, Overman M J, Eng C, Morelli M P, Jiang Z-Q, Luthra R, Meric-Bernstam F, Maru D, Scheet P, Kopetz S, Vilar E
Abstract excerpt
BACKGROUND: KRAS mutations in codons 12 and 13 are present in ∼40% of all colorectal cancers (CRC). Activating mutations in codons 61 and 146 of KRAS and in codons 12, 13, and 61 of NRAS also occur but are less frequent. The clinicopathologic features and gene expression profiles of this latter subpopulation of RAS-mutant colorectal tumors have not yet been clearly defined but in general are treated similarly to...
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