Article
[Detection of KRAS,NRAS and BRAF gene mutations in colorectal carcinoma].
Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Apr 2015
Zhang Keping, Xu Jie, Yan Lixu, Liu Xunhua, Xu Fangping, Liu Yanhui
Abstract excerpt
OBJECTIVE: To investigate mutations frequencies of KRAS,NRAS and BRAF genes in colorectal carcinoma. METHODS: Tissue specimens from 200 colorectal cancer patients at diagnosis were collected and subject to KRAS,NRAS and BRAF mutation analyses by PCR-based direct DNA sequencing targeting exons 2, 3 and 4 of KRAS gene, exons 2, 3 and 4 of NRAS gene and exon 15 of BRAF gene. RESULTS: Activating mutations were...
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