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Article

Delineating the role of the HLA-DR4 "shared epitope" in susceptibility versus resistance to develop arthritis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2008

Taneja Veena, Behrens Marshall, Basal Eati, Sparks Josh, Griffiths Marie M, Luthra Harvinder, David Chella S

Abstract excerpt

In humans, HLA-DR alleles sharing amino acids at the third hypervariable region with DRB1*0401(shared epitope) are associated with a predisposition to rheumatoid arthritis, whereas DRB1*0402 is not associated with such a predisposition. Both DRB1*0402 and DRB1*0401 occur in linkage with DQ8 (DQB1*0302). We have previously shown that transgenic (Tg) mice expressing HLA-DRB1*0401 develop collagen-induced arthritis....

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Share to Arthritis, Experimental
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA-DQ Antigens

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

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Share to T-Lymphocytes, Regulatory

Source

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Identifiers

PMID: 18684978
DOI: 10.4049/jimmunol.181.4.2869
PMCID: PMC3932339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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