Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New humanized HLA-DR4-transgenic mice that mimic the sex bias of rheumatoid arthritis.

Arthritis and rheumatism - 1 Jan 2007

Taneja Veena, Behrens Marshall, Mangalam Ashutosh, Griffiths Marie M, Luthra Harvinder S, David Chella S

Abstract excerpt

OBJECTIVE: To generate a mouse model that can mimic human rheumatoid arthritis (RA). A major difference between RA in humans and collagen-induced arthritis (CIA) in mice is the lack of sex bias and autoantibodies in the animal model. We used DRB1*0401-transgenic mice to understand the role of DR4 in susceptibility and sex bias in RA. METHODS: A transgenic mouse was generated that lacked all endogenous mouse class...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Experimental
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to HLA-DR4 Antigen

Share to Joints

Share to Sex Factors

Share to Spleen

Share to Thymus Gland

Source

Identifiers

PMID: 17195209
DOI: 10.1002/art.22213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New humanized HLA-DR4-transgenic mice that mimic the sex bias of rheumatoid arthritis.PMID 17195209Read ↗

Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice.Semantic proximity Read ↗

To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice.Semantic proximity Read ↗

Role of HLA class II genes in susceptibility/resistance to inflammatory arthritis: studies with humanized mice.Semantic proximity Read ↗

Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: studies in mice and men.Semantic proximity Read ↗

Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis.Semantic proximity Read ↗

HLA transgenic mice as humanized mouse models of disease and immunity.Semantic proximity Read ↗

An HLA-DR1 Transgene Confers Susceptibility to Collagen-induced Arthritis Elicited with Human Type II CollagenSemantic proximity Read ↗

Delineating the role of the HLA-DR4 "shared epitope" in susceptibility versus resistance to develop arthritis.Semantic proximity Read ↗

HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis.Semantic proximity Read ↗

HLA class II transgenic mice as models of human diseasesSemantic proximity Read ↗

Mice expressing HLA-DQ6alpha8beta transgenes develop polychondritis spontaneously.Semantic proximity Read ↗

Increased susceptibility to collagen-induced arthritis in female mice carrying congenic Cia40/Pregq2 fragments.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.