Article
HLA-DQ6/8 double transgenic mice develop auricular chondritis following type II collagen immunization: a model for human relapsing polychondritis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1998
Bradley D S, Das P, Griffiths M M, Luthra H S, David C S
Abstract excerpt
We have generated transgenic (tg) mice expressing HLA-DQ8alphabeta (DQA1*0301/DQB*0302) or HLA-DQ6alphabeta (DQA1*0103/DQB1*0601) molecules lacking endogenous murine class II expression (A beta0) to investigate the ability of these HLA class II to present type II collagen (CII) and induce collage...
Topics
- Animals
- Arthritis
- Autoantibodies
- Autoimmune Diseases
- Collagen
- Disease Models, Animal
- Ear Cartilage
- Ear Deformities, Acquired
- Female
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- Humans
- Immunization
- Immunoglobulin G
- Male
- Mice
- Mice, Transgenic
- Polychondritis, Relapsing