HLA class II transgenic mice as models of human diseases

doi:10.1111/j.1600-065x.1999.tb01307.x

Article

HLA class II transgenic mice as models of human diseases

1 Jun 1999

Abstract excerpt

Predisposition to develop various autoimmune disorders has been associated with certain HLA class II molecules but there is a lack of information on the pathophysiological role of HLA genes in conferring susceptibility. Various experimental animal models of autoimmune disease have been studied to address the role of immune response genes. To study the interactions involved between class II molecules (DQ and DR)...

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