Article
Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2003
Adarichev Vyacheslav A, Valdez Juan C, Bárdos Tamás, Finnegan Alison, Mikecz Katalin, Glant Tibor T
Abstract excerpt
Collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA) are murine models for rheumatoid arthritis both in terms of their pathology and genetics. Using the F(2) hybrids of the CIA-susceptible, but PGIA-resistant DBA/1 mice, and the CIA-resistant, but PGIA-susceptible BALB/c mice, our goals were to 1) identify both model-specific and shared loci that confer disease susceptibility, 2) determine...
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