Article
To B or not to B: role of B cells in pathogenesis of arthritis in HLA transgenic mice.
Journal of autoimmunity - 1 Sept 2011
Behrens Marshall, Smart Michele, Luckey David, Luthra Harvinder, Taneja Veena
Abstract excerpt
Population studies have shown that amongst all the genetic factors linked with autoimmune disease development, MHC class II genes are the most significant. Experimental autoimmune arthritis resembling human rheumatoid arthritis (RA) can be induced in susceptible strains of mice following immunization with type II collagen (CIA). We generated transgenic mice lacking endogenous class II molecules and expressing...
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