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Article

Expression of the AID protein in normal and neoplastic B cells.

Blood - 15 Nov 2004

Pasqualucci Laura, Guglielmino Roberta, Houldsworth Jane, Mohr Jessica, Aoufouchi Said, Polakiewicz Roberto, Chaganti R S K, Dalla-Favera Riccardo

Abstract excerpt

Somatic hypermutation (SHM) targets primarily the immunoglobulin variable region (IgV) genes in germinal center (GC) B cells, thereby allowing antibody affinity maturation. A malfunction of SHM, termed aberrant somatic hypermutation (ASHM), was found in about 50% of diffuse large B-cell lymphomas (DLBCLs), leading to mutations in the 5' sequences of multiple genes, including oncogenes. Although the SHM mechanism...

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Identifiers

PMID: 15304391
DOI: 10.1182/blood-2004-04-1558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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