VHDJH to JH joining is not blocked in mu-chain-producing pre-B cells, implying the breakdown of allelic exclusion.

doi:10.1111/j.1744-313x.1990.tb00891.x

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Article

VHDJH to JH joining is not blocked in mu-chain-producing pre-B cells, implying the breakdown of allelic exclusion.

Journal of immunogenetics - 1 Dec 1990

Sugiyama H, Komori T, Minami Y, Sakato N

Abstract excerpt

Intracytoplasmic mu-positive pre-B cells (mu+VH315- cells) transformed with Abelson virus continuously produced cells (mu+VH315+ cells) that were double-stained by anti-mu and anti-VH315 antibodies which specifically recognized the immunoglobulin heavy chain variable region identical or closely r...

Topics

Abelson murine leukemia virus
Alleles
Animals
B-Lymphocytes
Cell Line, Transformed
Gene Expression
Genes, Immunoglobulin
Hematopoietic Stem Cells
Immunogenetics
Immunoglobulin mu-Chains

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