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Article

VH replacement rescues progenitor B cells with two nonproductive VDJ alleles.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2006

Lutz Johannes, Müller Werner, Jäck Hans-Martin

Abstract excerpt

Inaccurate VDJ rearrangements generate a large number of progenitor (pro)-B cells with two nonproductive IgH alleles. Such cells lack essential survival signals mediated by surface IgM heavy chain (muH chain) expression and are normally eliminated. However, secondary rearrangements of upstream VH gene segments into assembled VDJ exons have been described in mice transgenic for productive muH chains, a process...

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Source

Identifiers

PMID: 17082616
DOI: 10.4049/jimmunol.177.10.7007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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