Article
An unusual type of V-J joining diversifies the primary repertoire of mouse lambda 1 light chains.
Nature - 1 Jan 2000
Karjalainen K, Coleclough C
Abstract excerpt
It is well established that B lymphocytes can achieve an almost unlimited antibody repertoire by using combinations of at least three different basic mechanisms. First, the mammalian genome has multiple, distinct germline variable (V), joining (J) and diversity (D) gene segments which can presumably combine randomly to give V-D-J joins in the heavy (H)-chain loci and V-J joins in the light (L)-chain loci during...
Topics
- Animals
- Antibody Diversity
- B-Lymphocytes
- Base Sequence
- DNA
- Genetic Variation
- Immunoglobulin J-Chains
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region
- Immunoglobulin lambda-Chains
- Isoelectric Focusing