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Article

Immature B cells can pass through a VHDJH/germ line state in the Ig H chain gene rearrangements.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1990

Oka Y, Sugiyama H, Tsukada S, Kishimoto S

Abstract excerpt

SPL2-1-2, an Ig- murine immature B cell line, was established by the infection of immature B cells with tsOS-59, a temperature-sensitive mutant of Abelson murine leukemia virus. Southern blot and DNA cloning and sequencing analysis showed that SPL2-1-2 had a nonproductive VHQ52.DSP2.JH3 and a germ line (G) allele (VHDJH-/G), and that D to JH joinings followed by VH to DJH joinings progressed on the G allele...

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PMID: 2358678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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