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Article

E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development.

PLoS genetics - 18 Jul 2008

Kulkarni Madhura, Smith Harold E

Abstract excerpt

Poly-ubiquitination of target proteins typically marks them for destruction via the proteasome and provides an essential mechanism for the dynamic control of protein levels. The E1 ubiquitin-activating enzyme lies at the apex of the ubiquitination cascade, and its activity is necessary for all subsequent steps in the reaction. We have isolated a temperature-sensitive mutation in the Caenorhabditis elegans uba-1...

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Identifiers

PMID: 18636104
DOI: 10.1371/journal.pgen.1000131
PMCID: PMC2443343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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