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Article

Immunohistochemical analysis reveals variations in proteasome tissue expression in C. elegans.

PloS one - 1 Jan 2017

Mikkonen Elisa, Haglund Caj, Holmberg Carina I

Abstract excerpt

The ubiquitin-proteasome system (UPS) plays a crucial part in normal cell function by mediating intracellular protein clearance. We have previously shown that UPS-mediated protein degradation varies in a cell type-specific manner in C. elegans. Here, we use formalin-fixed, paraffin-embedded C. elegans sections to enable studies on endogenous proteasome tissue expression. We show that the proteasome...

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PMID: 28817671
DOI: 10.1371/journal.pone.0183403
PMCID: PMC5560697

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