Article
Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.
PloS one - 25 Jan 2011
Selman Colin, Partridge Linda, Withers Dominic J
Abstract excerpt
We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice. However, no effect on lifespan was observed in male Irs1 null mice. We suggested at the time that the lack of any effect in males might have been due to a sample size issue. While such lifespan studies are essential to our...
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