Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening.

Aging cell - 1 Feb 2010

Liao Chen-Yu, Rikke Brad A, Johnson Thomas E, Diaz Vivian, Nelson James F

Abstract excerpt

Chronic dietary restriction (DR) is considered among the most robust life-extending interventions, but several reports indicate that DR does not always extend and may even shorten lifespan in some genotypes. An unbiased genetic screen of the lifespan response to DR has been lacking. Here, we measured the effect of one commonly used level of DR (40% reduction in food intake) on mean lifespan of virgin males and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caloric Restriction
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Life Expectancy

Share to Longevity

Share to Mice, Inbred Strains

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 19878144
DOI: 10.1111/j.1474-9726.2009.00533.x
PMCID: PMC3476836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening.PMID 19878144Read ↗

Genetic variation in responses to dietary restriction--an unbiased tool for hypothesis testing.Semantic proximity Read ↗

Fat maintenance is a predictor of the murine lifespan response to dietary restriction.Semantic proximity Read ↗

Regulators of health and lifespan extension in genetically diverse mice on dietary restrictionSemantic proximity Read ↗

Regulators of health and lifespan extension in genetically diverse mice on dietary restrictionSemantic proximity Read ↗

Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan.Semantic proximity Read ↗

Dietary restriction impacts health and lifespan of genetically diverse mice.Semantic proximity Read ↗

Reevaluation of the effect of dietary restriction on different recombinant inbred lines of male and female mice.Semantic proximity Read ↗

Lifespan modulation in mice and the confounding effects of genetic background.Semantic proximity Read ↗

Murine weight loss exhibits significant genetic variation during dietary restriction.Semantic proximity Read ↗

Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation researchSemantic proximity Read ↗

Genetic regulation of fasting-induced longevity effectsSemantic proximity Read ↗

Genome-wide analysis reveals distinct genetic mechanisms of diet-dependent lifespan and healthspan in <i>D. melanogaster</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.