Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.

Aging cell - 1 Nov 2020

Yuan Rong, Musters C J M, Zhu Yun, Evans Tracy R, Sun Yujie, Chesler Elissa J, Peters Luanne L, Harrison David E, Bartke Andrzej

Abstract excerpt

Epidemiological studies of human longevity found two interesting features, robust advantage of female lifespan and consistent reduction of lifespan variation. To help understand the genetic aspects of these phenomena, the current study examined sex differences and variation of longevity using previously published mouse data sets including data on lifespan, age of puberty, and circulating insulin-like growth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian rhythm and melatonin
Share to Dietary Effects on Health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genetics, Aging, and Longevity in Model Organisms

Share to Longevity

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 33105070
DOI: 10.1111/acel.13263
PMCID: PMC7681063

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.PMID 33105070Read ↗

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levelsSemantic proximity Read ↗

Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains.Semantic proximity Read ↗

Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation.Semantic proximity Read ↗

Sex- and age-dependent genetics of longevity in a heterogeneous mouse populationSemantic proximity Read ↗

Mice as a Mammalian Model for Research on the Genetics of AgingSemantic proximity Read ↗

Why do sexes differ in lifespan extension? Sex-specific pathways of aging and underlying mechanisms for dimorphic responsesSemantic proximity Read ↗

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening.Semantic proximity Read ↗

Regulators of health and lifespan extension in genetically diverse mice on dietary restrictionSemantic proximity Read ↗

Deep Phenotyping and Lifetime Trajectories Reveal Limited Effects of Longevity Regulators on the Aging Process in C57BL/6J MiceSemantic proximity Read ↗

Genetically heterogeneous mice exhibit a female survival advantage that is age‐ and site‐specific: Results from a large multi‐site studySemantic proximity Read ↗

Regulators of health and lifespan extension in genetically diverse mice on dietary restrictionSemantic proximity Read ↗

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.