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Article

Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2014

Lorenzini Antonello, Salmon Adam B, Lerner Chad, Torres Claudio, Ikeno Yuji, Motch Susan, McCarter Roger, Sell Christian

Abstract excerpt

Reduced signaling through the IGF type 1 (IGF-1) receptor increases life span in multiple invertebrate organisms. Studies on mammalian longevity suggest that reducing levels of IGF-1 may also increase life span. However, the data are conflicting and complicated by the physiology of the mammalian neuroendocrine system. We have performed life-span analysis on mice homozygous for an insertion in the Igf1 gene. These...

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Identifiers

PMID: 23873963
DOI: 10.1093/gerona/glt108
PMCID: PMC3968822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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