Article
Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".
Science (New York, N.Y.) - 23 May 2008
Selman Colin, Lingard Steven, Gems David, Partridge Linda, Withers Dominic J
Abstract excerpt
Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
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