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Article

Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms.

Journal of pharmacological sciences - 1 Jan 2011

Jutabha Promsuk, Anzai Naohiko, Kimura Toru, Taniguchi Atsuo, Urano Wako, Yamanaka Hisashi, Endou Hitoshi, Sakurai Hiroyuki

Abstract excerpt

We analyzed the functional properties of five nonsynonymous single nucleotide polymorphisms (SNPs) in the sodium-phosphate transporter NPT4 gene (SLC17A3) using the Xenopus oocyte expression system. NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [(14)C]para-aminohippurate, [(3)H]bumetanide, [(3)H]estrone sulfate, and [(14)C]urate, when each variant clone was expressed in the...

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PMID: 21282933
DOI: 10.1254/jphs.10228sc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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